The McMackin Lab harnesses MRI and electrophysiological methods, including transcranial magnetic stimulation (TMS), electromyography (EMG) and electroencephalography (EEG), to understand and develop clinically meaningful measures of neurological diseases, including Amyotrophic Lateral Sclerosis (ALS)/Motor Neurone Disease (MND) and Huntington’s disease. The lab also investigates the fundamental human physiology underpinning electrophysiology-based measures, aiming to improve their interpretation and application. In addition, the lab has an interest in understanding sex differences in human physiology and the influence of hormonal fluctuations on physiological processes and neurophysiological measures.